Learn more about ZEMBRACE™ SymTouch™ (sumatriptan injection), an acute migraine treatment. Treximet® (sumatriptan and naproxen sodium) is a selective 5-HT1B/1D receptor agonist and antiinflammatory indicated for the acute treatment of migraine, with or without aura, in adults and pediatric patients 12 years of age and older who have a clear migraine diagnosis. Imitrex (sumatriptan) is a selective serotonin receptor agonist used in oral, intranasal or injectable dosage form to treat migraine headaches. Imitrex is available as a generic drug. The ONZETRA Xsail difference: Breath Powered ® delivery. How it works. ONZETRA allows you to control the delivery of your medication. The unique device uses the power of your own breath to deliver medicine directly to the back of your nose–it’s sumatriptan taken differently! Sumatriptan is a headache medicine that narrows blood vessels around the brain. Sumatriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms. Imitrex Injection (sumatriptan succinate) is a selective serotonin receptor agonist used to treat migraine headaches. Imitrex is available as a generic drug. Whether you’ve been prescribed ZEMBRACE SymTouch and oral sumatriptan, or just ZEMBRACE SymTouch, the Dual Savings Card* can help you save both ways. severe tightness, pain, pressure, or heaviness in your chest, throat, neck, or jaw pain or discomfort in your arms, back, neck, jaw, or stomach Sumatriptan is a headache medicine that narrows blood vessels around the brain. Sumatriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms. ONZETRA ® Xsail ® is a prescription medication approved for the acute treatment of migraine, with or without aura in adults. ONZETRA Xsail is used for people who have been told by a healthcare provider that they have migraine headaches.